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The discussion emphasizes the drugs mechanism of action, highlighting the pharmacodynamic ratio of alpha- to beta-blockade (approximately 1:3 orally and 1:7 intravenously), which shifts meaningfully depending on route of administration

Patient experience is valuable, but good science requires more than perception alone

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In February 2024, Ozempic and Mounjaro prescriptions reached 2 and 1.2 million, respectively

Driven by efficacy data showing weight loss of up to 22.5% 1 and a cultural phenomenon that outpaced manufacturing capacity, these drugs entered a prolonged period of FDA-declared shortage